My research is mainly to study the mechanism of prostate cancer tumorigenesis and development. The research field involves the epithelial-mesenchymal transition of prostate cancer cells, tumor heterogeneity and the role of cancer stem cells in response to therapeutic resistance. We focus on the molecular mechanisms of prostate cancer development, including bone metastasis, neuroendocrine differentiation, signal transduction of castration resistance, biomarkers, and new treatment strategies.

We recently focused on using molecular biology, histological diagnosis, cell biology and animal model mechanisms to explore the neuroendocrine differentiation mechanism and metabolic pathway disorders of prostate cancer. We explored the drug resistance and neuroendocrine differentiation mechanism of prostate cancer after androgen deprivation treatment.

 

We study biomarkers that can predict the development of prostate cancer, provide immediate precision medicine for men at high risk of prostate cancer, and avoid unnecessary surgery for low-risk patients.